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10.1016/j.heliyon.2023.e22977 114

When exposed to temperatures above the recommended range, peptide bonds may break down, reducing the concentration of active medication in each injection and potentially diminishing therapeutic response

When metformin alone is insufficient, NICE recommends considering the addition of one of several medication classes: SGLT2 inhibitors (such as dapagliflozin, empagliflozin, or canagliflozin) work by increasing glucose excretion through the kidneys