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Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays

A meta-analysis has demonstrated that studies in adults which used higher doses of prednisolone (1 mg/kg/day, maximum 60 mg) have a higher remission rate and also have more steroid-related side effects than those which used a lower dose (0.5 mg/kg/day)

In particular, histone deacetylases (HDAC) are potential therapeutic targets in different neurological conditions (Grff and Tsai, Another mechanism of epigenetic regulation is mediated by microRNAs, which cause the degradation of genes involved in the development and progression of BBB dysfunction (Figure 2) (Ma et al., Figure 2)