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4 Immunopharmacological implications Physiological levels of ROS, which are present in all living organisms, can activate both signaling pathways such as MAPK and ERK and transcription factors such as NF-B ( However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Figure 3)

496 Diabetic patients tend to have worse outcomes after acute myocardial infarction, and hyperglycemia increases the hearts susceptibility to I/R injury, which in turn induces multiple forms of programmed cell death, including ferroptosis

10.1021/bi051344a Biochemistry 9 ChanK