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Most patients reported single substance exposures ( n = 146, 96%) but concomitant antihyperglycemic medication use was recorded in 51 patients (34%)

up to 24% in obesity trials) Constipation (6-17% of patients, dose-dependent) Abdominal pain and dyspepsia (6-11% of patients) These gastrointestinal effects are typically most pronounced during dose escalation and often diminish over time as patients develop tolerance

Your PlexusDx care team can help you adjust your calendar reminder or delivery schedule if you find weekly timing difficult to remember

This is due to the fact that in CGD the production of the ROS, hydrogen peroxide, is deficient and so these catalase-positive microorganisms can defeat the limited levels of ROS produced by phagocytic cells