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This gap emphasizes the critical need for integrated, multidisciplinary, and sustainable care strategies to support long-term behavioral change ( The presence of complex comorbidities in a subset of participantssuch as syndromic or hypothalamic obesity, neurodevelopmental disorders, and chronic systemic diseasesmay influence therapeutic responsiveness, potentially attenuating the magnitude of treatment effects

The situation with sitagliptin is even more pronounced, with a total of 28 reported cases of biliary malignancies associated with its use

Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives

Ferroptosis is closely related to spontaneous preterm birth, and PLA2G6 can alleviate ferroptosis caused by GPX4 inhibition during pregnancy in mice (128)