Polycystic Ovary Syndrome (PCOS) - 5-10% of women 50% lower glutathione levels compared to women without PCOS 3-4x higher risk of preeclampsia 3x higher risk of gestational diabetes Critical concern: With 50% lower baseline glutathione, the "safe" dose is effectively cut in half IVF Conception - 2-5% of births (up to 6-8% in some countries) Women who conceive via IVF experience dramatic antioxidant depletion: 70% reduction in plasma antioxidant capacity 83% reduction in follicular fluid antioxidant capacity 50-100%+ increase in oxidative stress markers With over 5 million babies born via IVF globally, this represents a large high-risk population Gallbladder Dysfunction - 10% of pregnant women Up to 10% develop gallstones or biliary sludge Intrahepatic cholestasis: 0.4-10% of pregnancies CRITICAL: Fatal Outcomes Documented at Therapeutic Doses The first case of a pregnant woman with intrahepatic cholestasis who died from liver failure after taking THERAPEUTIC/NORMAL doses of acetaminophen was reported in 2022
Kaufman-Shriqui V, Navarro DA, Salem H, Boaz M
Advisers to the Food and Drug Administration (FDA) will soon hold a meeting about whether to ease restrictions on access to some research peptides, a group of drugs with a zealous following and thin evidence to support them
6, PP 435 [online] Available at: Gov.uk (2021) McCance and Widdowsons The Composition of foods integrated data set (CoFID) [online] Available at: Guaita, A., Brunelli, L., Davin, A., Poloni, T.E., Vaccaro, R., Gagliardi, S., Pansarasa, O
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