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Indeed, DPP-4 acts as a receptor or costimulatory protein in immunomodulatory signaling processes in various immune cells such as CD8 + and CD4 + T cells, B cells, and macrophages, and hydrolyzes different sites of chemokines and interleukins that are part of bone remodeling

In lipopolysaccharide (LPS)-induced intestinal injury mouse models, the intestine rapidly responds to ischemic damage, characterized by increased GLP-1 secretion following intestinal barrier injury (56)

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Diabetes is prone to cause macrovascular disease, microvascular disease and other complications, which seriously affects the quality of life of patients and increases the burden of disease