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At MPR 0.5, the adjusted HR was quite similar to that in the main analysis (HR 0.87 [0.71-1.06]), but this became lower at MPR 0.75 (HR 0.75 [0.60 0.95]) and lower yet at MPR 0.95 (HR 0.62 [0.46 0.84]) When excluding subjects with follow-up times shorter than 6 months, 25,390 individuals remained, and the unadjusted HR for MOF was found to be 0.86 [0.731.02] for GLP-1 RAs compared to DPP-4is
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Developing such therapies necessitates a detailed understanding of the cellular machinery that choreographs GLUT4 movement throughout the cell and, critically, how this machinery is altered in insulin resistance
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