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There are several mechanisms through which cyclodextrins improve bioavailability

In previously published protocols different types of derivatization reagents (CMQT or CMLT), different pH of the buffer used in the protocols (7.4) and shorter time of sample reduction and derivatization (3 min) were applied (Tables 3 and 4.) Changing the conditions of reduction and derivatization increases the efficiency of this process, which may give higher final concentrations of the analytes

doi: 10.1001/jamapediatrics.2013.1045 23 IdornTKnopFKJrgensenMBChristensenMHolstJJHornumMet al

Supporting Immune Cell Function Immune cells, such as lymphocytes, macrophages, and dendritic cells, rely on glutathione for optimal function