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Ethical approval This research has been conducted using the UK Biobank Resource under application number 42468 and other large studies and consortia providing publicly available summary statistics (Additional file 1: Table S1 and Additional file 2: Fig

This view dominated for nearly a century

Common Side Effects Peripheral edema (swelling of ankles or feet) most frequent Flushing (warmth or redness of face) Headache Dizziness or lightheadedness Fatigue Less Common / Rare Side Effects Palpitations or rapid heartbeat Nausea or abdominal discomfort Hypotension (low blood pressure) Gingival hyperplasia (gum overgrowth) rare Rash or itching Important Notes Usually well-tolerated Swelling in the legs is dose-related Can be used safely in most adults with other comorbidities Monitor blood pressure regularly

It is entirely possible to have an oily skin type that is also deeply dehydrated