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Phosphatidylserine 400 to 800 mg/d (Monteleone 1992, Hellhammer 2004) Administration of 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise, suggesting that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the HPA axis (Monteleone 1992)

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These musculoskeletal implications underscore why muscle preservation strategies are an essential component of weight managementparticularly for those with existing orthopedic concerns

Statins, diuretics, antidepressants, antipsychotics, some oral contraceptives, and steroids are all known to cause nighttime leg cramps