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In addition to evaluating the risk of bias using the RoB 2 tool for RCTs and the ROBINS-I tool for non-randomized studies, we also assessed the overall quality of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework

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I mean you can look at this animal and not know anything about mice or work with them and be like, that animal looks like it's, of course mice life spans are only like two and a half years, but like 500 years old