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Next, we had a small sample size ( n = 14) in the DLPFC which made it difficult to make comparisons between regions (ACC vs

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A40 is comparatively benign and may even be protective (reviewed in ex vivo AD-model) or hippocampal A42 injections in vivo likely serve as a feasible prototype for cognition-relevant neuronal network dynamics in AD, since several synaptic and neuronal AD features has been replicated ( However, it has been observed that acute A42 application could induce a biphasic effect on neuronal networks consisting in an initial decrease of activity followed by overexcitation ( in vivo ( AD Animal Models 3xTg AD mice model exhibits hypo-excitable synaptic transmission, reduced paired-pulse facilitation (PPF), and normal LTP at 7 days old in the hippocampal CA1 area in response to HFS of Schaffer collaterals