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Moderate-severe steatosis was evident from 12 weeks and all mice demonstrated advanced steatosis (score 3) from 24 to 36 weeks followed by a gradual decline in NAS explained by reduced steatosis score from 48 weeks and onwards (Figs

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Side effects may temporarily increase around a dose change, then settle as the body adapts

The three nitric oxide synthases (NOS)inducible NOS (iNOS), endothelial NOS (eNOS), and neuronal NOS (nNOS)interact with hydrogen sulfide (H 2 S) to regulate oxidative stress and tumor growth