Combining leptin treatment with leptin sensitizers may thus help overcome leptin resistance and, also obesity, as a result [14]
When to contact your GP or diabetes team : Persistent vomiting preventing fluid intake Severe abdominal pain, especially if radiating to the back (possible pancreatitis) Right upper abdominal pain, fever or jaundice (possible gallbladder problems) Signs of dehydration (dark urine, dizziness, reduced urination) Unexplained hypoglycaemia if on combination therapy New or worsening visual symptoms (especially if you have diabetic retinopathy) Allergic reactions (rash, swelling, breathing difficulties) Most patients tolerate GLP-1 medications well once past the initial adjustment period

NAC may help by supporting antioxidant defenses and reducing oxidative stress, though its effects vary depending on the population and fertility issue being studied.32 In men, one randomized trial found that 600mg of NAC, selenium, or the combination improved semen parameters, with the combination producing stronger effects than either ingredient alone.23 In women undergoing assisted reproduction, NAC has also been studied for oocyte and embryo quality, though this research is still relatively early and not definitive.24 PCOS NAC has attracted particular interest in PCOS, where insulin resistance, inflammation, and oxidative stress often overlap.17 Researchers think NAC may help by improving insulin sensitivity and reducing oxidative stress, which may, in turn, support ovulation and reproductive function
This helps in managing weight and improving overall metabolic health