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However, this frequently results in diminishing returns and increased side effects

Nevertheless, if beneficial effects on strength, similar to those demonstrated with GH79 can be shown, GH secretagogues could provide a well-tolerated clinical approach for treating or preventing sarcopenia, and perhaps, even forestall the inevitability of age-associated decline in function and independence. The decrease in GH/IGF-1 levels is thought to arise from insufficient stimulation, indicating a use it or lose it dilemma

Cox, Lehninger Principles of Biochemistry, 7th Edition, W

Liu Y, Cheng C, Gao H, Zhu XJ, He X, Zhou MX, et al