N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency
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Memory dysfunction is frequently comorbid with age-related neurodegenerative diseases, such as Alzheimer's disease (AD) ( Memory dysfunction seriously impacts performance of routine tasks necessary for a productive and healthy life, including the ability to maintain gainful employment and compliance with treatment plans ( Synthesis, Structure, Transport and Cellular Targets of Neurosteroids Synthesis and Translocation Neurosteroid synthesis involves translocation of cholesterol across the mitochondrial membrane by transport proteins, such as the steroidogenic acute regulatory protein (StAR protein), the translocator protein (TSPO), voltage-dependent anion channel (VDAC) protein and the adenine nucleotide transporter (ANT) protein ( The sulfation and desulfation of neurosteroids further alters both the pharmacokinetic and pharmacodynamic properties of these endogenous neuromodulators ( Neurosteroids and their sulfated conjugates can be characterized based on their core backbone structures as pregnanes, pregnenes, androstanes, progesterones, and deoxycorticosterones
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