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40.6 g of crude Semaglutide was weighed, dissolved in 1500 mL of a mixed solvent of 25% acetonitrile and 75% water, and purified using Waters 2545 RP-HPLC system with a wavelength of 218 nm, a chromatographic column of 50 x 250 mm reverse phase C18 column, a column temperature of 45C, and NH 4 Ac acetonitrile as a mobile phase system

While gastrointestinal side effects are common with both, tirzepatide may actually be better tolerated for some people

When prescribed appropriately and combined with lifestyle modifications such as nutrition and physical activity, some patients may experience weight reduction

This can cause severe nausea, vomiting, and even a hardened mass of old, half-digested food called a bezoar