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FIGURE 10 Oxidative stress, associated with high dose MTX, triggers a systemic inflammatory response where proinflammatory cytokines further contribute to tissue damage ( During stressful conditions, such as MTX-induced oxidative damage, unresolved ER stress leads to the accumulation of unfolded proteins promoting apoptosis (Figure 1)

reported that never-smoking patients with chronic beryllium disease (CBD) displayed higher extracellular GPX activity in BALF than ex-smoking CBD patients 49

Mechanistically, FSP1 reduces CoQ and vitamin K, generating radical-trapping antioxidants (RTAs) that effectively terminate lipid peroxidation chain reactions at the plasma membrane, thereby guarding against ferroptosis

Therefore, BPC 157 may improve gastrointestinal tract therapy