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What does the research say

As a result, vitamin B12 plays a significant role in the growth and operation of brain and nerve cells

Enzymatic Sensitivity Experiments: Analysing activation and inhibition patterns across multiple pathways

In animal reproduction studies, adverse effects on development were observed following intranasal administration of dihydroergotamine mesylate during pregnancy (decreased fetal body weight and/or skeletal ossification) in rats and rabbits or during pregnancy and lactation in rats (decreased body weight and impaired reproductive function in the offspring) at doses that were not associated with maternal toxicity (see Data)