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Traditionally GLP-1(9-36) was considered inactive, however more recent studies indicate that GLP-1(9-36) can contribute to inhibiting glucagon secretion by inhibiting voltage-gated calcium channels through a GPCR mechanism, an effect which reduces the number of glucagon containing vesicles that are available for exocytosis, thereby contributing the the decrease in glucagon secretion (Figure 1)(Zheng et al, 2024)

But a newly published study from Scripps Clinic physicians offers evidence that less frequent options might be possible

Semaglutide GLP-1 Semaglutide has been shown to aid in weight loss by helping individuals feel fuller for longer and reducing cravings

Wegovy and Mounjaro, which have been selling rapidly in Korea, are included in the planned designation