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In the SURMOUNT-1 trial, tirzepatide produced average weight loss of: 5 mg dose: 15.0% body weight reduction 10 mg dose: 19.5% body weight reduction 15 mg dose: 20.9% body weight reduction These results came from 72 weeks of carefully titrated, medically supervised treatment

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However, this does not mean the combination is right for everyone

In addition, discrepancies between mRNA and protein expression levels, particularly for IL-6, were observed