These effects often decrease over time as the body adapts, but if intolerable, staying at a lower effective dose is a reasonable clinical decision
The association that developed between the response and the independent elements was modeled using the following second-order polynomial equation: In the statistical model, the dependent variable is represented by Y, the independent variables by X i and X j , and the coefficients for the intercept, linear terms, quadratic terms, and interaction terms are denoted by 0 , i , ii , and ij , respectively
[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Kang K.W., Ok M., Lee S.K
The fates of NAD + precursors appear to depend on the tissue distribution and expression levels of NAD + biosynthetic enzymes, nucleosidase, and presumptive transporters for each specific precursor