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Despite its popularity, it is important to note that Melanotan 2 is not approved by regulatory bodies like the FDA, and its use can be associated with various health risks

doi: 10.3389/fcell.2025.1623959 Received 06 May 2025 Accepted 04 August 2025 Published 20 August 2025 Volume 13 - 2025 Edited by Valerie Kouskoff, The University of Manchester, United Kingdom Reviewed by Soumya Ranjan Jena, Ravenshaw University, India Vinod Reddy Lekkala, University of California, San Francisco, United States Updates Copyright 2025 Feng and He

Inhibition of the TRPM7 channel weakens ferroptosis in rheumatoid arthritis chondrocytes by suppressing the PKC-NOX4 axis [154, 155]