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Manifestations of hepatic oxidative damage include dysregulation of lipid metabolism (leading to steatosis), hepatocyte degeneration and death, and activated immune response (leading to inflammation and fibrosis/cirrhosis)

In addition, GPX1-GPX6 and 7, GPX2-GPX5, and GPX3-GPX6 and 7 pairs showed very high structural similarity with 94 structural overlaps

Table 1 Specificity of AsGGT1, AsGGT2, and AsGGT3 for -glutamyl donor substrates