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The intracellular signaling pathways implicated in GLP-1s central regulatory effects likely include cyclic cAMP-PKA and phospholipase C-protein kinase C (PLC-PKC), among others [13]

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How Weight-Loss Drugs Escaped the Diabetes Clinic GLP-1 receptor agonists were developed and approved for type 2 diabetes, with obesity approval following only after trials like STEP and SURMOUNT showed consistent, significant weight loss details we cover in Part 1 on how these drugs work

Specifically, it means there are too many free radicals and not enough antioxidants