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Proc Natl Acad Sci USA 100:30773082

They may be beneficial in conditions characterized by oxidative stress and inflammation, such as neurodegenerative diseases, liver diseases, and in the management of side effects associated with chemotherapy and radiation therapy

If these antioxidant defences are insufficient or redox signalling is altered, then oxidants are able to damage the organismfor example, oxidants can destroy the cell membrane and block the action of major enzymes and processes, a phenomenon also referred to as distress (Figure 1) [1,2]