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References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al

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The microbiota regulates the expression of tight junction proteins (such as ZO-1 and occludin) in intestinal epithelial cells by releasing specific metabolites and signaling molecules, thereby safeguarding the structural and functional integrity of the intestinal barrier (86)

The combination of lymph node transfer and excisional procedures in bilateral lower extremity lymphedema: clinical outcomes and quality of life assessment with long-term follow-up