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[14] [15] Additional symptoms may include glossitis (a sore, red tongue), angular cheilitis (cracks at the corners of the mouth), and gastrointestinal disturbances
(3) age-appropriate cancer-screening status, specifically colonoscopy per USPSTF guidelines and PSA for men over 40
This suggests that polyphenols are prone to degradation in biological systems, potentially reducing their bioavailability and biological efficacy (110112)
While these bioactive compounds offer numerous health benefits at low doses, high doses or prolonged use can lead to adverse effects, including organ-specific toxicity, pro-oxidant activity, and drug interactions
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