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Taken together, the researchers concluded that thyroid function may affect mast cells, and that mast cell degranulation could affect thyroid function.[ref] In patients with autoimmune thyroid disease, mast cells infiltrate the thyroid gland and then degranulate.[ref] Animal studies show that hypothyroidism (low thyroid hormone levels) increases the number of mast cells by up to 4.5-fold

The facet joints in the spine may increase in size due to osteoporosis or Pagets disease, forming bone spurs, narrowing the passageways, and ultimately compressing the nerve roots

Y., Rosenfeld, S

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