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Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]

However, the influence of high-altitude factors may cause an increase in the bodys production of oxygen-free radicals or a decrease in the speed of scavenging oxygen-free radicals, which will cause oxidative stress [18,19,20,21,22]

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