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However, in acute intensive care unit (ICU) settings, where patients require mechanical respiratory support, a multitude of factors including infection, accumulation of inflammatory cells, airway dehydration, reduced cough reflexes, supra-normal oxygenation, and mechanical stress from ventilation can lead to changes in mucus characteristics and increased mechanical impedance to mucociliary clearance

Cancer cells metabolically fertilize the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors

This is due to cumulative damage to mitochondrial DNA which would otherwise have been reduced by glutathiones antioxidant activity and protective effects