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DOI: 10.2174/1389557520666200628032116

Specific metabolic changes observed during GLP-1 treatment include: Improved insulin sensitivity , allowing cells to use glucose more efficiently Reduced hepatic glucose production , contributing to better glycaemic control Changes in body composition , with loss of both fat mass and some lean tissue Alterations in lipid metabolism , often resulting in improved cholesterol profiles Body composition studies suggest that lean tissue loss typically accounts for approximately 20-30% of total weight lost during GLP-1 therapy, though this varies considerably between individuals and depends on concurrent physical activity and protein intake

The rapid elimination of the increased pressure in the ligated superior sagittal sinus, rapid elimination of the severe portal and caval hypertension and aortal hypotension, and rapid collateral vessels recruitment, abrogated venous and arterial thrombosis and recovery of the organs lesions, consistently occurred

GLP-1 reduces hunger: GLP-1 helps regulate blood sugar levels and control appetite