This analysis was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement

Common symptoms of MTHFR gene mutation, or MTHF indicators, include: Chronic fatigue Miscarriage or multiple miscarriages Histamine intolerance Increased risk of cancer Hormone imbalance Cardiovascular and thromboembolic diseases, specifically blood clots, stroke, embolism, and heart attacks Depression, anxiety, bipolar disorder or schizophrenia Colon cancer Acute leukemia Chronic pain Oestrogen dominant conditions such as fibrocystic breasts, fibrocystic ovaries, heavy periods, uterine fibroids, endometriosis, and severe premenstrual syndrome Allergies, asthma, hives Migraines ADD or ADHD Learning difficulties at school / you may find it hard to concentrate Elevated liver enzymes Elevated red cell folate Chronic constipation or diarrhoea Low vitamin B12 levels Dizziness Elevated homocysteine levels 2 MTHFR variants can also lead to serious genetic disorders such as homocystinuria, anencephaly and spina bifida

Sources: FDA Warning Letter, USA TODAY Investigation, MDL Update MDL-3094, JAMA Ophthalmology NAION Study, KFF Health Tracking Poll, Reuters MDL-3163
Fo = Folate Can regulate the neurotransmitters (like serotonin) that affect mood and energy levels, combatting the fatigue and brain fog so common in menopause