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If you have any of the following, make sure to talk about it with your doctor: A history of pancreatitis Severe gastrointestinal diseases You are pregnant or breastfeeding A personal or family history of medullary thyroid cancer or multiple endocrine neoplasia If youre undergoing surgery, you may need to stop taking GLP-1 beforehand

44,45 In a meta-analysis of 48 RCTs including 27,729 participants, the overall incidence of GI adverse events was reported to be 11.6%, with nausea identified as the most common symptom (21.4%)

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In addition, postprandial glycemia is an independent cardiovascular risk factor and predicts all-cause mortality (76), and accordingly, represents a specific target for the treatment of type 2 diabetes