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Additionally, clinical trials with long-acting dual or triple agonists targeting the glucagon receptor have demonstrated a marked suppressive effect on circulating amino-acids in both humans and animals [66, 67]

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On the other hand, when looking at the time above range measured by continuous glucose measuring, results were found to be 10.3% with the combined treatment, 28.1% with cagrilintide treatment, and 23.7% with semaglutide treatment [2]

This intranasal delivery method can enhance the overall efficiency and bioavailability of peptide therapy while potentially reducing the risk of systemic side effects