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Due to the nature of this process, it is purported that the compound may ensure that levels are never allowed to reach a concentration at which they may begin to have unwanted effects

Salt forms of semaglutide are problematic

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It identified legitimate methodological concerns (assay heterogeneity in the pharmacology comparison, Weber effect as a confounder in the FAERS analysis, uncertainty bounds on the efficacy extrapolation) and recommended specific textual revisions