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The same FDA document mandates post-marketing trials to demonstrate that the novel agent does not increase cardiovascular risk by more than 30% compared to placebo (henceforth these trials were named cardiovascular outcome trial), if premarketing studies did not already demonstrate this

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For some, however, these symptoms might be persistent enough to affect their quality of life, leading to what's humorously termed a "Hangover." Serious side effects can include pancreatitis and kidney problems, which require immediate medical attentionthink "Stat!" In terms of safety, Semaglutide bears a boxed warning for thyroid C-cell tumors, a red flag for at-risk patients