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The ischemia generates inflammation which then meets the oxygen in the blood (which can be converted to superoxide) and inflammatory cells (which can create free radicals)

Interestingly, some of these bioactive peptides are specifically generated after limited proteolysis of denatured egg proteins [67], after boiling

Furthermore, Hcy accelerates endothelial cell (EC) aging by promoting apoptosis and other forms of cell death, including D-gasdermin-dependent pyroptosis [17]

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