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Li H, Sun Y, Yao Y, Ke S, Zhang N, Xiong W, et al

The simplicity of the procedure is precisely what creates risk in certain settings

We observed a consistent increase in sensitivity, or reduced IC 50 value, for mutant cells treated with doxycycline but not parental OVCAR5 cells, indicating that induction of mutant p53 sensitized cells to APR-246 (Fig