retatrutide for diabetes type 2 🩺 in diabetes: TRANSCEND-T2D-1 Phase 3 results → HbA1c ↓2.0% + weight ↓16.8% at 40 weeks. A triple agonist that tackles both glycemia and obesity simultaneously. 📊💊 Ref: Lilly Lilly Prepares for Retatrutide FDA

Importantly, gut-centered actions mesh with classic pharmacology: combining berberine with metformin in diabetic mice produced a greater fall in blood glucose than either drug alone and generated a distinct microbiota signaturehigher Akkermansia and Verrucomicrobia , and lower Proteobacteriaalongside higher circulating metformin levels [67]

It plays a vital role in detoxification, cellular repair, and protecting the body from oxidative stress caused by free radicals

However, the dietary changes and altered digestive transit associated with these medications may indirectly affect stool appearance

The trial found it was well tolerated with injection site reactions as the most common side effect