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The enhanced potency is due to the markedly decreased binding of human LR3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs

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doi: 10.3389/fneur.2024.1356662 Received 15 December 2023 Accepted 10 May 2024 Published 19 June 2024 Volume 15 - 2024 Edited by Dominic D'Agostino, University of South Florida, United States Reviewed by Anandakumar Shunmugavel, Case Western Reserve University, United States Xuehua Liu, Capital Medical University, China Updates Copyright 2024 Fogarty and Harch