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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Silberstein S

Ongoing and future trials are investigating whether these drugs can benefit brain health, especially when used before cognitive symptoms appear

Patients who fail to respond adequately to semaglutide often respond better to tirzepatide, not because of dose differences but because the dual mechanism addresses different pathways

Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research