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Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting

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Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

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This intermediate is nucleophilically attacked by the active site tyrosine residue (Tyr114) to form a covalent vinylether adduct, leading to inhibition of the enzyme (Figure 6A) (Yadav et al., 2019)

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