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GPX4 stands as a central inhibitor of ferroptosis, forming the cornerstone of anti-peroxidation defense [14]

All failed to deliver beneficial effects except acetyl-L-carnitine which showed improved ALS Functional Rating Scale in small number of patients in a phase II clinical trial

Among lncRNAs, MALAT1, lincRNA-p21, TUG1, and H19 have been identified as key modulators: MALAT1 associates with UVB-induced senescence and photoaging in dermal fibroblasts and may have analogous roles in melanocytes, while lincRNA-p21 mediates p53-dependent apoptosis and cell cycle arrest to prevent malignant transformation 107

Ninety-seven percent were White, 2% were Black or African American and less than 1% were Asian