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Microglia and astrocytes in the CNS are activated to release inflammatory factors and damage neurons, and in the peripheral immune system, alterations in blood immune cell subsets and function, and elevated inflammatory factors correlate with central inflammatory and neurodegenerative changes, but the consistency is influenced by clinical phenotype and disease stage [160, 161]

Importantly, the combination of PL and CB-839 synergistically reduced cell viability and LPO levels, accompanied by significant GSH depletion

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