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While no significant within-group changes were observed in STAT3, TGF-1 in the L-carnitine group, STAT3 levels increased significantly in the control group compared to baseline

Upon examination of mitochondria by electron microscopy, both the 5FU-treated and control groups exhibited comparable mitochondrial structures

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The literature assessment served as an additional filtering and validation step, ensuring that subsequent in vitro characterization focused on compounds with either novel or insufficiently explored links to metabolic regulation