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Animals Fifteen-week-old male Wistar rats and Wistar/BonnKobori (KOB) rats (KBT Oriental, Saga, Japan) were used

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Rats were kept in stainless steel cages (6/each) and monitored for a week before the experiments commencement in a controlled environment with consistent lighting (12 h light/12 h dark cycle), 30%40% humidity and 25 C room temperature

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