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The current paradigm to address non-pulmonary vein sources of AFib is to extend the ablation to include more atrial tissue, which has had limited success
Second, PCOS involves multiple cell types and signaling pathways, and other potential regulatory mechanisms have not yet been revealed
Perturbations in the RAAS are implicated in the progression of cardiovascular dysfunction and nephropathy associated with poorly controlled T2DM [266]
Understanding the physiology of natural GLP-1 provides essential context for appreciating why pharmaceutical modifications were necessary to harness its therapeutic potential for chronic disease management, particularly in type 2 diabetes and obesity treatment
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