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Current animal model systems do not fully recapitulate the pathophysiological conditions in human IC/BPS, and targeting specific molecular pathway disruption in animal models might serve as a better option than existing models

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/ Start with one supplement for 710 days before adding the second

second, hydrated and activated platinum ions are positively charged and can be driven by the 180 mV transmembrane negative potential of the inner mitochondrial membrane to cross the inner membrane and enter the mitochondrial matrix (Kleih et al